Atoderm Intensive baume

• The Skin Barrier Therapy TM patent biologically prevents attaching of staphylococcus aureus on atopic skin
• Moisturizing power (+23%) ⁽¹⁾
• Lipigenium TM complex immediately physically restores a protective film on the surface of the skin, preventing allergens from penetrating ⁽²⁾  while biologically forming a healthy skin barrier
• Soothing and anti-itching actions (3.4)

Very good tolerance – Cream texture ⁽⁵⁾ - Easy to spread – Penetrates quickly – Non-greasy – Non-shiny ⁽⁴⁾

Clinically tested on patients with dry to very dry skin on face and body, atopic dermatitis patients.

* p<0.01, Student’s t-test, after 28 days

(1)In vivo evaluation of transepidermal water loss (TEWL) reduction after applying Atoderm Intensive Baume – 11 volunteers (aged 23 – 69 years old) with dry or very dry skin on the body with twice daily application. South Africa. 2018
(2)Evaluation of the preventive effect on pollen allergens accumulation in the pilous follicle. France. 2021
(3)Evaluation of tolerance assessment of Atoderm Intensive Baume on skin dryness on patients with atopic dermatitis – 150 patients (aged more than three months) with one or twice application. Bulgaria. 2015
(4)Evaluation of Atoderm Intensive Baume of skin condition improvement– 176 patients (aged < 18 years old) sensitive, very dry, irritated to atopic skin.
(5)User test on Atoderm Intensive Baume on paediatric population – 15 patients (aged 5 – 27 months) with dry to very dry skin. Poland. 2013
(6)User test on Atoderm Intensive Baume – 20 patients (aged 23 – 69 years old) with dry to very dry skin on the face and body. France. 2018

> CLINICAL RESULTS
After 28 days application of Atoderm Intensive Baume, the efficacy in rebuilding the skin barrier was evaluated by measuring transepidermal water loss (TEWL). The results show a significant reduction of (-23%) ** in TEWL that reflects a reinforcement of skin barrier(1).

ACTION ON PREVENTIVE EFFECT ON POLLEN ALLERGENS
Explants were obtained from an abdoplasty of Caucasian male. They were distributed into batches:

• 1 with allergen incubation for 6 hours
• 1 with application of Atoderm Intensive Baume followed 10 minutes later by application of the allergen.

Application of Atoderm Intensive baume before application of the allergen completely prevented its accumulation along the hair follicle (-110%***). The relative surface covered by allergen was significantly lower compared to untreated control ⁽²⁾.

ACTION ON ATOPIC DERMATITIS
After 56 days of application of Atoderm Intensive Baume, the clinical signs of Atopic Dermatitis were evaluated, the result showed significantly decreases in: ⁽³⁾
Feeling of dryness (-84%)*

• Sensation of tightness (-93%)*
• Insomnia (-92%)*
• Roughness (-85%)*
• Pruritus (-85%)*

After 21 days of application of Atoderm Intensive Baume, the average intensity of the objective clinical signs was significantly reduced  ⁽⁴⁾:

• Redness / Irritation (-64.8%) ****
• Oozing or vesicles (-80%) ****
• Dryness (-68%) **** 
• Scratching lesions (-75%) ****

TOLERANCE  
Atoderm Intensive Baume is very well tolerated on the ocular level and on the cutaneous level, no reaction of skin or eye signs were observed ⁽⁶⁾.

* p<0.05, Anova model, after 28 days
** p<0.01, Student’s t-test, a fter 28 days
*** p<0.001 Student t-test, after 6 hours
****p<0.001, Wilcoxon test, after 21 days

> PATIENTS FEEDBACKS
100 % of the patients found that the product protects the skin. Skin is moisturized immediately and all day long. ⁽⁵⁾
For more than 80% of the patients, the skin is hydrated, comfortable and restored. Moreover, over 90% of them evaluated Atoderm Intensive Baume as an anti-iching product. ⁽⁶⁾

(1) In vivo evaluation of transepidermal water loss (TEWL) reduction after applying Atoderm Intensive Baume – 11 volunteers (aged 23 – 69 years old) with dry or very dry skin on the body with twice daily application. South Africa. 2018
(2) Evaluation of the preventive effect on pollen allergens accumulation in the pilous follicle. France. 2021
(3) Evaluation of tolerance assessment of Atoderm Intensive Baume on skin dryness on patients with atopic dermatitis – 150 patients (aged more than three months) with one or twice application. Bulgaria. 2015
(4) Evaluation of Atoderm Intensive Baume of skin condition improvement– 176 patients (aged < 18 years old) sensitive, very dry, irritated to atopic skin.
(5) User test on Atoderm Intensive Baume on paediatric population – 15 patients (aged 5 – 27 months) with dry to very dry skin. Poland. 2013
(6) User test on Atoderm Intensive Baume – 20 patients (aged 23 – 69 years old) with dry to very dry skin on the face and body. France. 2018