Preventing side effects of acne treatments thanks to two specific dermo-cosmetic products
Fauger A.1, Chavagnac-Bonneville M. 1,2, Graizeau C.1,2 and Sayag M. 1
1NAOS Group, Research and Development Department, Aix-en-Provence, France
2NAOS Institute of Life Science, Aix-en-Provence, France
5 min read
Related topics
Acne / Oily
Acne treatments, like keratolytic and isotretinoin treatments, are known to induce many skin side effects like skin barrier alteration and dehydration, potentially leading to poor compliance.
To prevent these side effects and improve compliancy, two specific dermo-cosmetic products were assessed in acne subjects.
In a prospective multicenter clinical study, 106 subjects (mean age 17.8 ± 3.6 years; 81% women) under keratolytic treatment applied since the beginning (D0) of their acne treatment the product S twice a day (morning/evening), and 50 subjects (mean age 19.2 ± 3.4 years; 78% women) under isotretinoin applied the product H once a day (morning). An assessment of the acne severity and the intensity of clinical signs was made at D0. During 28 days the symptoms were evaluated by the subjects as well as the product’s efficacy and tolerability.
The majority of subjects under keratolytic treatment presented a moderate acne (69.8%) and those under isotretinoin presented severe acne (61.2%). Dryness was not exacerbated in both groups and even decreased significantly at D28 with the product S (-33.3%). Similarly, the following criteria were not worsened, and even decreased significantly after 28 days: redness (S: -50.0%; H: -18.8%), burning sensations (-40.0% for both) and tingling sensation (S: -66.7%; H: -46.2%). The subjects evaluated a soothing effect for both products showing a significant increase between D1 and D28 (+33.3% for both), and a significant moisturizing effect (S: +31.3%; H: +19.0%). Overall efficacy was rated good to excellent for 75.2% and 80.0% of subjects with product S and product H, respectively. Both products in association with the corresponding treatment showed good tolerance.
By preventing skin side effects induced by keratolytic and isotretinoin treatment, these two dermo-cosmetic products could increase patients’ compliance to their medical treatment and so their efficacy.
Fauger A.1, Chavagnac-Bonneville M. 1,2, Graizeau C.1,2 and Sayag M. 1
1NAOS Group, Research and Development Department, Aix-en-Provence, France
2NAOS Institute of Life Science, Aix-en-Provence, France